Bilateral intranuclear Ophthalmoplegia | Neurology

Bilateral internuclear ophthalmoplegia associated with bilateral exotropia, also referred to as Wall-Eyed Bilateral Internuclear Ophthalmoplegia (WEBINO), is a rare neuro-ophthalmological syndrome characterized by limitation in bilateral eye adduction, bilateral exotropia, and nystagmus upon abduction. | Neurology

INTRANUCLEAR OPHTHALMOPLEGIA During horizontal gaze, the MLF on each side of the brain stem enables abduction of one eye to be coordinated with adduction of the other. The MLF connects the following structures: Sixth cranial nerve nucleus (which controls the lateral rectus, responsible for abduction) Adjacent horizontal gaze center (paramedian pontine reticular formation) Contralateral third cranial nerve nucleus (which controls the medial rectus, responsible for adduction) The MLF also connects