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You need to up your iron levels but supplementing makes your histamine worse? Here’s what might be causing it If you take iron and suddenly feel flushed, itchy, anxious, wired, refluxy, head pressure, or like you’re about to panic… it’s not “in your head.” It’s often a mast cell gut enzyme iron-handling issue. Here’s what’s happening physiologically: 1. Iron is pro-oxidative If iron isn’t properly bound/handled, it can increase oxidative stress → mast cell activation → histamine release. 2. Iron
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