Malignant Hyperthermia vs Neuroleptic Malignant Syndrome is a high-yield differential diagnosis (your matrix/grid, bow tie type of a question). Both conditions share the same core signs and symptoms, remember HAM: •⁠ ⁠High fever (104–105°F) •⁠ ⁠Altered mental status •⁠ ⁠Muscle rigidity And both are treated with dantrolene! How do we tell them apart? We look at the cause: •⁠ ⁠Malignant Hyperthermia (MH): congenital reaction to anesthesia and neuromuscular-blocking agents •⁠ ⁠Neuroleptic Malignant