T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently ...

T cells lie at the heart of adaptive immunity, recognising peptide antigens via the T cell receptor (TCR) and undergoing activation only when signals from co-stimulatory receptors complement antigen ...

Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.

Alternative therapies that aid the body's immune system to fight bacteria have shown promise in addressing the global threat of antibiotic resistance. University of Queensland researchers have found ...

Researchers screening roughly 400 transcription factors found that disabling a single protein, NFIL3, allowed CAR T-cells to ...

Researchers at Columbia University’s Sadelain lab and University Hospital Tubingen used CRISPR gene editing to knock out the transcription factor NFIL3 in engineered CAR T cells, and the modified ...