Escherichia coli remains at the forefront of recombinant protein production, owing to its rapid growth, well-characterised genetics and the ease with which it can be genetically manipulated. The ...

Codon optimization is a central strategy in recombinant protein production, enabling genes from one organism to be efficiently expressed in another. Conventional methods typically replace ...

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Proteins need to fold into specific shapes to perform their functions in cells, but they occasionally misfold, which can prevent them from properly functioning and even lead to disease. Subscribe to ...

The Rutgers group of collaborators found that the E. coli genome encodes at least 150 small proteins, most of which are functionally uncharacterized. Small bacterial proteins are defined as having ...

A new high-throughput study that used publicly available data shows that E. coli proteins containing a structure called a non-covalent lasso entanglement (NCLE) are more likely to misfold and, if they ...