Aneuploidy, or abnormal chromosome content, is the most common characteristic of human solid tumours. Aneuploidy might contribute to tumour formation and is associated with acquired resistance to some ...

The anaphase-promoting complex/cyclosome (APC/C) is an ubiquitin ligase that functions during mitosis. Here we identify the transcriptional regulator, transcriptional intermediary factor 1γ, TIF1γ, as ...

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the ...

(A) Histone staining images and OI-DIC density imaging of human living cells in the interphase (the phase between cell divisions, left) and mitotic phase (right). The bottom two rows are OI-DIC ...

Prognostic significance of circulating tumor cell (CTC) levels at various times during first- and second-line chemotherapy for metastatic breast cancer (MBC). This is an ASCO Meeting Abstract from the ...

Writing in his journal about the scientists of his era, Henry David Thoreau bemoaned their blindness to significant phenomena: "The question is not what you look at, but what you see." More than 150 ...

This is a preview. Log in through your library . Abstract During anaphase, mitotic spindles elongate up to five times their metaphase length. This process, known as anaphase B, is essential for ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 26 (Dec. 19, 2000), pp. 14548-14553 (6 pages) Meiosis is the developmental program by which diploid ...

The chromosome pairs separate; half of the chromosomes move toward one end of the cell, the other half, to the other end. The chromosomes' sister chromatids do not separate as they do in mitosis.

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the ...

For more than 125 years, scientists have been peering through microscopes, carefully watching cells divide. Until now, however, none has actually seen how cells manage to divide precisely into two ...