Nucleotide synthesis—the production of the basic components of DNA and RNA—is essential for cell growth and division. In most ...

Researchers from Karolinska Institutet have discovered how mammalian cells prevent the gradual buildup of harmful mutations in mitochondrial DNA, the small but vital genome that powers every cell. The ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

Nucleotide synthesis-the production of the basic components of DNA and RNA-is essential for cell growth and division. In most animal cells, this process depends closely on properly functioning ...