This granulomatous reaction may be viewed as a frustrated attempt by the immune system to neutralize antigen. The antigen is trapped within the granuloma and in this location the macrophages secrete ...

While these animals retain the regenerative ability throughout adulthood, most mammals, including mice and humans, lose this capacity shortly after birth. 4 Scientists are interested in determining ...

Aging immune cells known as senescent macrophages are emerging as critical players in cancer progression. Rather than defending the body, these aged cells undergo profound functional shifts that ...

Melanoma cells with the cell membrane protein CD44 stained in red and the nucleus in blue. Dil-labelled extracellular vesicles taken up by cancer cells are shown in green. Image by Kaisa Mäki-Mantila.