Clinical and genomic characteristics between DDR germline and somatic mutations in pan-cancer. Programmed cell death ligand 1 (PD-L1) expression landscape and its relationship with tumor mutational ...

Suzhou Kintor Pharmaceuticals Inc. has identified proteolysis targeting chimera (PROTAC) compounds comprising cereblon (CRBN) binding moiety covalently linked to Myc proto-oncogene protein (c-Myc), ...

Pancreatic cancer is one of the deadliest cancers worldwide, with a five-year survival rate of 13%. The poor prognosis is due in part both to late detection and the cancer’s capacity to adapt and ...

Targeting a non-encoding stretch of RNA may help shrink tumors caused by an aggressive type of brain cancer in children, according to new research in mice reported March 8 in Cell Reports by Johns ...

Results from a phase 2 study of triplet blockade of the IL-27, PD-(L)1, and VEGF pathways with casdozokitug (casdozo, CHS-388) in combination with atezolizumab and bevacizumab in patients with ...

There is intense effort to identify transcriptional targets of the c-Myc proto-oncogene that can account for its role in cell growth and division. In the January 16 Nature, Natividad Gomez-Roman and ...

Cancer-associated genes called oncogenes are well known to stimulate cell growth and division — causing tumors to balloon and spread. But now, researchers at the Stanford School of Medicine and ...