Thousands of our cells successfully divide every day. They replicate their DNA and then separate so that each of the new cells has the same complement of chromosomes. If the process goes wrong and ...

Chromosome motions to the spindle midzone, or congression, is an efficient process in mitosis. After nuclear envelope breakdown (NEBD) at prometaphase, the kinetochore, an organelle at the centromere ...

In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

As a cell divides, its DNA -the genetic material- is duplicated and condensed into structures called chromosomes, which are carefully organized and distributed so that each daughter cell acquires a ...

(Phys.org) -- With the first-ever three-dimensional image of an isolated kinetochore – the bulky molecular machine that connects a chromosome to the long, thin microtubules that tug it to one end of a ...

The protein complex responsible for the distribution of chromosomes during cell division is assembled in the transition regions between heterochromatin and euchromatin. The centromere is a specialized ...

Scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. The kinetochore is vital to proper DNA ...

The kinetochore connects chromosomes to spindle microtubules, corrects attachment errors, and triggers the separation of sister chromatids. It is built from more than 100 proteins, grouped into around ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 15 (Apr. 12, 2005), pp. 5408-5413 (6 pages) The budding yeast kinetochore is comprised of >60 proteins ...

This is a preview. Log in through your library . Abstract Identification of proteins that couple kinetochores to spindle microtubules is critical for understanding how accurate chromosome segregation ...

For a living cell to divide successfully, each daughter cell must inherit the correct genetic material. In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a ...