Although the α-alkylation of ketones has already been established, the analogous reaction using aldehyde substrates has proven surprisingly elusive. Despite the structural similarities between the two ...

When synthesizing new compounds, it is advantageous to have reactants that are widely available and a simple method which produces a high yield of products with little waste (undesirable byproducts).

Matchmaking between ketones and olefins has never been easy. Although ketones readily pair up with many reagents, thanks to their ability to deprotonate and form nucleophilic enolates, olefins ...